Job Description

Overview Research Scientist, Computational Drug Design We are seeking a highly motivated and experienced computational chemist to join our Computational Drug Design group in Boston. This individual will be responsible for contributing to both hit/lead identification and optimization programs using methods encompassing all computational aspects of drug discovery. The right candidate's responsibilities include close interaction with interdisciplinary projects teams to identify and advance safe and efficacious molecules. In addition, this individual will work collaboratively with the global Data and Computational Sciences group to provide expertise in data analysis, cheminformatics, and physics-based methods development. Thus, this individual must demonstrate strong interpersonal skills and have demonstrated the ability to guide scientists in drug discovery. Key Duties and Responsibilities Apply computational chemistry methods and tools to accelerate the discovery and development of drug candidates, in close collaboration with chemists, structural biologists, biologists and other research project scientists Use timely decision making to ensure focus and delivery of key project objectives. Promote high levels of productivity and urgency Leverage physics-based methods, generative models and machine learning approaches to design new chemical entities Proactively work with other computational chemists and cheminformaticians to assess and develop new computational methodologies, create workflows and share successful methods Contribute to the further development of Vertex's computational chemistry capabilities with a focus on physics-based methods Seek out opportunities to improve Vertex's global R&D capabilities through collaboration with DMPK, Structural Biology, Safety Assessment, and other groups Knowledge and Skills Excellent interpersonal, communication and presentation skills In depth knowledge of physics-based methods and the state-of-the-art in computational chemistry and their application in drug discovery Experience with commercial and open-source molecular modeling and data mining software Knowledge of concepts related to drug discovery and development Strong solution-oriented attitude, spirit of innovation and creativity, good time and priority management Scripting and programming expertise in languages such as Python Education and Experience Ph.D. (or equivalent degree) in Computational Chemistry and 2-5 years of productive, relevant post-doctoral employment experience Experience in applying a wide array of molecular modeling methods to structure, ligand and fragment-based drug discovery projects Pay Range: $123,400 - $185,100 Disclosure Statement The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status In this Hybrid-Eligible role, you can choose to be designated as: 1) Hybrid : work remotely up to two days per week; or select 2) On-Site : work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com #J-18808-Ljbffr Vertex Pharmaceuticals Incorporated

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